The protective effect of trimetazidine against cisplatin-induced nephrotoxicity in rats
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منابع مشابه
The protective effect of trimetazidine against cisplatin-induced nephrotoxicity in rats.
Nephrotoxicity is a dose-limiting side effect of cisplatin (CSP). The study investigated the possible protective role of trimetazidine (TMZ) against CSP-induced nephrotoxicity in rats. Rats were divided into four groups; control, TMZ, CSP, and CSP + TMZ. The CSP group showed significant deterioration in kidney function with structural changes in the form of interstitial hemorrhage, glomeruli sh...
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Objective: The clinical use of cisplatin is highly restricted, because of its nephrotoxicity.In this study the protective effect of Nigella sativa (N. sativa) against cisplatin-induced nephrotoxicity was investigated in rats. Materials and Methods: In the current study, the effects of the administration of aqueous-ethanolic extract of N. sativa (100 and 200 mg/kg, BW) and vitamin E (100 mg/kg, ...
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متن کاملthe protective effect of nigella sativa against cisplatin-induced nephrotoxicity in rats
objective: the clinical use of cisplatin is highly restricted, because of its nephrotoxicity.in this study the protective effect of nigella sativa (n. sativa) against cisplatin-induced nephrotoxicity was investigated in rats. materials and methods: in the current study, the effects of the administration of aqueous-ethanolic extract of n. sativa (100 and 200 mg/kg, bw) and vitamin e (100 mg/kg, ...
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ژورنال
عنوان ژورنال: Canadian Journal of Physiology and Pharmacology
سال: 2016
ISSN: 0008-4212,1205-7541
DOI: 10.1139/cjpp-2015-0472